Article
Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2003
Maffucci Tania, Razzini Giorgia, Ingrosso Alessandra, Chen Hui, Iacobelli Stefano, Sciacchitano Salvatore, Quon Michael J, Falasca Marco
Abstract excerpt
The insulin receptor phosphorylates insulin receptor substrate (IRS) proteins on multiple tyrosine residues that act as docking sites to recruit a number of downstream signaling molecules. Here we show that IRS3 is localized both at the plasma membrane and in the nucleus. Interestingly, the nuclear localization of the protein is restricted to specific regions involved in mRNA processing and known as speckles. By...
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