Article
Insulin receptor structural requirements for the formation of a ternary complex with IRS-1 and PI 3-kinase.
Molecular and cellular endocrinology - 18 Sept 1996
Wilden P A, Rovira I, Broadway D E
Abstract excerpt
Insulin receptor substrate-1 (IRS-1) is a major substrate of the insulin receptor tyrosine kinase and is an intermediate in insulin signaling. Phosphotyrosyl-IRS-1 binds to other signaling proteins including phosphatidylinositol 3-kinase (PI 3-kinase). We examined the role of three insulin recept...
Topics
- Adenosine Triphosphate
- Animals
- Binding Sites
- CHO Cells
- Cricetinae
- Gene Expression
- Insulin
- Insulin Receptor Substrate Proteins
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphoproteins
- Phosphorylation
- Phosphotransferases (Alcohol Group Acceptor)
- Receptor, Insulin
- Structure-Activity Relationship
- Transfection