Article
Enhanced protein kinase B/Akt signalling in pituitary tumours.
Endocrine-related cancer - 1 Jun 2005
Musat M, Korbonits M, Kola B, Borboli N, Hanson M R, Nanzer A M, Grigson J, Jordan S, Morris D G, Gueorguiev M, Coculescu M, Basu S, Grossman A B
Abstract excerpt
Pituitary tumours have previously been shown to harbour several abnormalities that cause deregulation of the cell cycle, particularly down-regulation of expression of the cyclin-dependent kinase inhibitor p27. However, it has been unclear whether these are the primary initiating events, or are secondary to other more proximate alterations in signalling pathways. In other cellular systems the Akt signalling...
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