Article
Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease.
European journal of human genetics : EJHG - 1 Mar 2009
FitzGerald Liesel M, Patterson Briony, Thomson Russell, Polanowski Andrea, Quinn Stephen, Brohede Jesper, Thornton Timothy, Challis David, Mackey David A, Dwyer Terence, Foote Simon, Hannan Garry N, Stankovich James, McKay James D, Dickinson Joanne L
Abstract excerpt
Genetic heterogeneity is a difficulty frequently encountered in the search for genes conferring susceptibility to prostate cancer. To circumvent this issue, we selected a large prostate cancer pedigree for genome-wide linkage analysis from a population that is genetically homogeneous. Selected cases and first-degree relatives were genotyped with Affymetrix 10K SNP arrays, identifying a 14 Mb haplotype on...
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