Article
The genetic epidemiology of prostate cancer and its clinical implications.
Nature reviews. Urology - 1 Jan 2014
Eeles Rosalind, Goh Chee, Castro Elena, Bancroft Elizabeth, Guy Michelle, Al Olama Ali Amin, Easton Douglas, Kote-Jarai Zsofia
Abstract excerpt
Worldwide, familial and epidemiological studies have generated considerable evidence of an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations have been implicated. Genome-wide association studies (GWAS) have also identified 76 susceptibility loci associated with prostate cancer risk, which occur commonly but are of low penetrance. However, these mutations interact...
Topics
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Global Health
- Humans
- Male
- Molecular Epidemiology
- Morbidity
- Prostatic Neoplasms