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Article

Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.

The Journal of biological chemistry - 30 Nov 2012

Berger Gregory, Turpin Jocelyn, Cordeil Stéphanie, Tartour Kevin, Nguyen Xuan-Nhi, Mahieux Renaud, Cimarelli Andrea

Abstract excerpt

SAMHD1 is a newly identified restriction factor that targets lentiviruses in myeloid cells and is countered by the SIV(SM)/HIV-2 Vpx protein. By analyzing a large panel of Vpx mutants, we identify several residues throughout the 3-helix bundle predicted for Vpx that impair both its functionality and its ability to degrade SAMHD1. We determine that SAMHD1 is a strictly non-shuttling nuclear protein and that as...

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Identifiers

PMID: 23076149
DOI: 10.1074/jbc.M112.403816
PMCID: PMC3510820

Genes

SAMHD1

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Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.PMID 23076149Read ↗

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SAMHD1: a new insight into HIV-1 restriction in myeloid cellsSemantic proximity Read ↗

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Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation.Semantic proximity Read ↗

Identification and characterization of naturally occurring splice variants of SAMHD1.Semantic proximity Read ↗

HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1Semantic proximity Read ↗

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