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Article

SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein

1 Jan 2012

Abstract excerpt

Both human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) encode a unique set of accessory proteins that enhance viral replication in the host. Two similar accessory proteins, Vpx and Vpr, are encoded by HIV-2. In contrast, HIV-1 encodes Vpr but not Vpx. Recent studies have indicated that Vpx counteracts a particular host restriction factor, thereby facilitating reverse transcription in...

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PMID: 22908011
DOI: 10.3389/fmicb.2012.00297

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