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Article

SAMHD1: a new insight into HIV-1 restriction in myeloid cells

8 Jul 2011

Abstract excerpt

Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the cellular protein SAMHD1 to be this restriction factor, demonstrating that Vpx induces proteasomal degradation of SAMHD1 and enhances HIV-1 infection in...

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PMID: 21740548
DOI: 10.1186/1742-4690-8-55

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SAMHD1: a new insight into HIV-1 restriction in myeloid cellsPMID 21740548Read ↗

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