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Vpx is Critical for SIVmne infection of pigtail macaques

24 Apr 2012

Abstract excerpt

BACKGROUND: Viral protein X (Vpx) of SIV has been reported to be important for establishing infection in vivo. Vpx has several different activities in vitro, promoting preintegration complex import into the nucleus in quiescent lymphocytes and overcoming a block in reverse transcription in macrophages. Vpx interacts with the DDB1-CUL4-DCAF1 E3 ligase complex, which may or may not be required for the ascribed...

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PMID: 22531456
DOI: 10.1186/1742-4690-9-32

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