Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics.

Pharmacology & therapeutics - 1 Apr 2005

Johnson Andrew D, Wang Danxin, Sadee Wolfgang

Abstract excerpt

Functional polymorphisms that alter gene expression and mRNA processing appear to play a critical role in shaping human phenotypic variability. Intensive studies on polymorphisms affecting drug response have revealed multiple modes of altered gene function, frequently involving cis-acting regulatory sequence variants. Experimental and in silico methods have advanced the search for such polymorphisms, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Biotransformation
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Gene Expression Regulation

Share to Pharmaceutical Preparations

Share to Pharmacogenetics

Share to RNA, Messenger

Source

Identifiers

PMID: 15781120
DOI: 10.1016/j.pharmthera.2004.11.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics.PMID 15781120Read ↗

Transcriptional regulation and pharmacogenomics.Semantic proximity Read ↗

Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.Semantic proximity Read ↗

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome datasetSemantic proximity Read ↗

Regulatory polymorphisms and their contribution to interindividual differences in the expression of enzymes influencing drug and toxicant disposition.Semantic proximity Read ↗

Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.Semantic proximity Read ↗

Considerations for rare variants in drug metabolism genes and the clinical implications.Semantic proximity Read ↗

Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response.Semantic proximity Read ↗

Pharmacogenetics of drug metabolizing enzymes and transporters: effects on pharmacokinetics and pharmacodynamics of anticancer agents.Semantic proximity Read ↗

Clinically relevant genetic variations in drug metabolizing enzymes.Semantic proximity Read ↗

Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability - considerations for drug development.Semantic proximity Read ↗

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.Semantic proximity Read ↗

Global spectrum of population-specific common missense variation in cytochrome P450 pharmacogenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.