Article
A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2008
Pickard B S, Knight H M, Hamilton R S, Soares D C, Walker R, Boyd J K F, Machell J, Maclean A, McGhee K A, Condie A, Porteous D J, St Clair D, Davis I, Blackwood D H R, Muir W J
Abstract excerpt
Underactivity of the glutamatergic system is an attractive model for the pathophysiology of several major mental illnesses. We previously described a chromosome abnormality disrupting the kainate class ionotropic glutamate receptor gene, GRIK4/KA1, in an individual with schizophrenia and learning disability (mental retardation). We also demonstrated in a case-control study that two physically separated haplotypes...
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