Article
Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands.
Scientific reports - 2 Nov 2022
Chatterjee Mahasweta, Saha Sharmistha, Dutta Nilanjana, Sinha Swagata, Mukhopadhyay Kanchan
Abstract excerpt
Executive dysfunctions caused by structural and functional abnormalities of the prefrontal cortex were reported in patients with Attention deficit hyperactivity disorder (ADHD). Owing to a higher expression of the glutamate ionotropic receptor kainate type subunit 1 (GluK1), encoded by the GRIK1 gene, in brain regions responsible for learning and memory, we hypothesized that GRIK1 might have a role in ADHD. GRIK1...
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