Article
Double-strand break DNA repair genotype predictive of later mortality and cancer incidence in a cohort of non-smokers.
DNA repair - 1 Jan 2009
Neasham David, Gallo Valentina, Guarrera Simonetta, Dunning Alison, Overvad Kim, Tjonneland Anne, Clavel-Chapelon Francoise, Linseisen Jakob P, Malaveille Christian, Ferrari Pietro, Boeing Heiner, Benetou Vassiliki, Trichopoulou Antonia, Palli Domenico, Crosignani Paolo, Tumino Rosario, Panico Salvatore, Bueno-De-Mesquita H Bas, Peeters Petra H, van Gib Carla H, Lund Eiliv, Gonzalez Carlos A, Martinez Carmen, Dorronsoro Miren, Barricarte Aurelio, Navarro Carmen, Quiros Josè R, Berglund Goran, Jarvholm Bengt, Khaw Kay Tee, Key Timothy J, Bingham Sheila, Diaz Tormo M Jose, Riboli Elio, Matullo Giuseppe, Vineis Paolo
Abstract excerpt
We followed-up for mortality and cancer incidence 1088 healthy non-smokers from a population-based study, who were characterized for 22 variants in 16 genes involved in DNA repair pathways. Follow-up was 100% complete. The association between polymorphism and mortality or cancer incidence was analyzed using Cox Proportional Hazard regression models. Ninety-five subjects had died in a median follow-up time of 78...
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