Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet.

doi:10.1016/j.jand.2017.09.025

Article

Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet.

Journal of the Academy of Nutrition and Dietetics - 1 Apr 2018

Corella Dolores, Ramírez-Sabio Judith B, Coltell Oscar, Ortega-Azorín Carolina, Estruch Ramón, Martínez-González Miguel A, Salas-Salvadó Jordi, Sorlí José V, Castañer Olga, Arós Fernando, Garcia-Corte Franscisco J, Serra-Majem Lluís, Gómez-Gracia Enrique, Fiol Miquel, Pintó Xavier, Saez Guillermo T, Toledo Estefanía, Basora Josep, Fitó Montserrat, Cofán Montserrat, Ros Emilio, Ordovas Jose M

Abstract excerpt

BACKGROUND: Oxidatively induced DNA damage, an important factor in cancer etiology, is repaired by oxyguanine glycosylase 1 (OGG1). The lower repair capacity genotype (homozygote Cys326Cys) in the OGG1-rs1052133 (Ser326Cys) polymorphism has been associated with cancer risk. However, no information is available in relation to cancer mortality, other causes of death, and modulation by diet. OBJECTIVE: Our aim was...

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Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet.

Abstract excerpt

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