Article
Clustered DNA lesion sites as a source of mutations during human colorectal tumourigenesis.
Mutation research - 10 Nov 2008
Radford Ian R, Lobachevsky Pavel N
Abstract excerpt
The role of gene mutations in tumourigenesis is well understood, however, the mechanism(s) by which they arise are less clear. Indeed, the common assumption that tumourigenic mutations are the result of DNA replication errors is apparently contradicted by the very low division frequency of the cells from which tumours are thought to arise (i.e. deep stem cells). As a potential solution to this paradox, we tested...
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