Article
Presence of a consensus DNA motif at nearby DNA sequence of the mutation susceptible CG nucleotides.
Gene - 10 Jan 2018
Chowdhury Kaushik, Kumar Suresh, Sharma Tanu, Sharma Ankit, Bhagat Meenakshi, Kamai Asangla, Ford Bridget M, Asthana Shailendra, Mandal Chandi C
Abstract excerpt
Complexity in tissues affected by cancer arises from somatic mutations and epigenetic modifications in the genome. The mutation susceptible hotspots present within the genome indicate a non-random nature and/or a position specific selection of mutation. An association exists between the occurrence of mutations and epigenetic DNA methylation. This study is primarily aimed at determining mutation status, and...
Topics
- Consensus Sequence
- CpG Islands
- DNA
- DNA (Cytosine-5-)-Methyltransferase 1
- Epigenesis, Genetic
- Humans
- Mutation
- Nucleotide Motifs
- Protein Binding