Sequence specificity in CpG mutation hotspots.

doi:10.1016/0014-5793(96)01075-7

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Article

Sequence specificity in CpG mutation hotspots.

FEBS letters - 4 Nov 1996

Ollila J, Lappalainen I, Vihinen M

Abstract excerpt

CpG dinucleotides are efficiently methylated in vertebrate genomes except in the CpG islands having a high C+G content. Methylated CpGs are the single most mutated dinucleotide. Sequences surrounding disease causing CpG mutation sites were analyzed from locus-specific mutation databases. Both tet...

Topics

Agammaglobulinaemia Tyrosine Kinase
Agammaglobulinemia
Base Sequence
DNA Methylation
Dinucleoside Phosphates
Factor VIII
Genes, p53
Genetic Linkage
Hemophilia A
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Phenylalanine Hydroxylase
Phenylketonurias
Point Mutation
Protein-Tyrosine Kinases
X Chromosome

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