Article
Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes.
Oncogene - 17 Apr 2003
Woerner Stefan M, Benner Axel, Sutter Christian, Schiller Marian, Yuan Yan P, Keller Gisela, Bork Peer, Doeberitz Magnus von Knebel, Gebert Johannes F
Abstract excerpt
DNA mismatch repair deficiency is observed in about 15% of human colorectal, gastric, and endometrial tumors and in lower frequencies in a minority of other tumors thereby causing insertion/deletion mutations at short repetitive sequences, recognized as microsatellite instability (MSI). Evolution of tumors, including those with MSI, is a continuous process of mutation and selection favoring neoplastic growth....
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