Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction.

Journal of periodontal research - 1 Aug 2008

Lin Z, Sugai J V, Jin Q, Chandler L A, Giannobile W V

Abstract excerpt

BACKGROUND AND OBJECTIVE: Platelet-derived growth factor-BB is a potent mediator of tooth-supporting periodontal tissue repair and regeneration. A limitation of the effects of topical platelet-derived growth factor-BB application is its short half-life in vivo. Gene therapy has shown strong promise for the long-term delivery of platelet-derived growth factor in both skin ulcer healing and periodontal tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Becaplermin
Share to Culture Media, Serum-Free
Share to Gingiva

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphotransferases

Share to Platelet-Derived Growth Factor

Share to Proto-Oncogene Proteins c-sis

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Receptor, Platelet-Derived Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 18823454
DOI: 10.1111/j.1600-0765.2008.01089.x
PMCID: PMC2583112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction.PMID 18823454Read ↗

Gene transfer and expression of platelet-derived growth factors modulate periodontal cellular activity.Semantic proximity Read ↗

Platelet-Derived Growth Factor Gene Delivery Stimulates <i>ex Vivo</i> Gingival RepairSemantic proximity Read ↗

Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors.Semantic proximity Read ↗

Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.Semantic proximity Read ↗

PDGF signaling in cells and mice.Semantic proximity Read ↗

Alpha5 and alpha2 integrin gene transfers mimic the PDGF-B-induced transformed phenotype of fibroblasts in human skin.Semantic proximity Read ↗

PDGF-BB and IL-4 co-overexpression is a potential strategy to enhance mesenchymal stem cell-based bone regenerationSemantic proximity Read ↗

Lentiviral Transfection with the PDGF-B Gene Improves Diabetic Wound HealingSemantic proximity Read ↗

Induction of Platelet-derived Growth Factor B-chain Expression by Transforming Growth Factor-β Involves Transactivation by SmadsSemantic proximity Read ↗

Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.Semantic proximity Read ↗

Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta -induced phenotypic transformation.Semantic proximity Read ↗

Platelet-derived growth factor AB heterodimer interchain interactions influence secretion as well as receptor binding and activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.