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Article

Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.

The Biochemical journal - 1 Apr 2002

Cartel Nicholas J, Wang Jinxia, Post Martin

Abstract excerpt

Previously we have demonstrated that the phosphoinositide 3-kinase (PI-3K) signal-transduction pathway mediates platelet-derived growth factor (PDGF)-BB-induced glycosaminoglycan (GAG) synthesis in fetal lung fibroblasts. In the present study we further investigated the signal-transduction pathway(s) that results in PDGF-BB-induced GAG synthesis. Over-expression of a soluble PDGF beta-receptor as well as a...

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Identifiers

PMID: 11903042
DOI: 10.1042/0264-6021:3630019
PMCID: PMC1222446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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