Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lentiviral Transfection with the PDGF-B Gene Improves Diabetic Wound Healing

1 Aug 2005

Abstract excerpt

BACKGROUND: The treatment of diabetic wounds remains a difficult challenge. The present study investigates whether platelet-derived growth factor (PDGF) lentiviral gene therapy can improve diabetic wound healing in the diabetic db/dbmouse. METHODS: PDGF cDNA was cloned and lentiviral vectors were constructed with either the PDGF-B or green fluorescence protein (GFP) gene. A 2 x 2-cm full-thickness dermal wound...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to Virus-based gene therapy research
Share to Wound Healing and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16079687
DOI: 10.1097/01.prs.0000172892.78964.49

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lentiviral Transfection with the PDGF-B Gene Improves Diabetic Wound HealingPMID 16079687Read ↗

Phenotypical differences in connective tissue cells emerging from microvascular pericytes in response to overexpression of PDGF-B and TGF-β1 in normal skin in vivo.Semantic proximity Read ↗

Genetically Modified Human Epidermis Overexpressing PDGF-A Directs the Development of a Cellular and Vascular Connective Tissue Stroma When Transplanted to Athymic Mice–Implications for the Use of Genetically Modified Keratinocytes to Modulate Dermal RegenerationSemantic proximity Read ↗

Syndecan-4 enhances PDGF-BB activity in diabetic wound healing.Semantic proximity Read ↗

Inhibition of stromal cell-derived factor-1α further impairs diabetic wound healing.Semantic proximity Read ↗

Genetically modified human placenta-derived mesenchymal stem cells with FGF-2 and PDGF-BB enhance neovascularization in a model of hindlimb ischemiaSemantic proximity Read ↗

aFGF gene-modified adipose-derived mesenchymal stem cells promote healing of full-thickness skin defects in diabetic ratsSemantic proximity Read ↗

Topical Sonic Hedgehog Gene Therapy Accelerates Wound Healing in Diabetes by Enhancing Endothelial Progenitor Cell–Mediated Microvascular RemodelingSemantic proximity Read ↗

Particle-mediated gene transfer of PDGF isoforms promotes wound repair.Semantic proximity Read ↗

Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors.Semantic proximity Read ↗

Transfection with aFGF cDNA Improves Wound HealingSemantic proximity Read ↗

Overexpression of VEGF in dermal fibroblast cells accelerates the angiogenesis and wound healing function: in vitro and in vivo studiesSemantic proximity Read ↗

Alpha5 and alpha2 integrin gene transfers mimic the PDGF-B-induced transformed phenotype of fibroblasts in human skin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.