Article

PDGF-BB and IL-4 co-overexpression is a potential strategy to enhance mesenchymal stem cell-based bone regeneration

2020-05-07

Abstract excerpt

<title>Abstract</title> <p>Background Mesenchymal stem cell (MSC)-based therapy has the potential for immunomodulation and enhancement of tissue regeneration. Genetically modified (GM) MSCs that over-express specific cytokines, growth factors or chemokines have shown great promise in pre-clinical studies. In this regard, the anti-inflammatory cytokine Interleukin (IL)-4 converts pro-inflammatory M1 macrophages i...

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Literature Corpus work: 94850e86-b437-5090-a050-cde1268e7ba6
DOI: 10.21203/rs.3.rs-26399/v1

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