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Article

Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.

The American journal of pathology - 1 Nov 2006

Lederle Wiltrud, Stark Hans-Jürgen, Skobe Mihaela, Fusenig Norbert E, Mueller Margareta M

Abstract excerpt

Platelet-derived growth factor (PDGF) stimulates tumor growth and progression by affecting tumor and stromal cells. In the HaCaT skin carcinogenesis model, transfection of immortal nontumorigenic and PDGF-receptor-negative HaCaT keratinocytes with PDGF-B induced formation of benign tumors. Here, we present potential mechanisms underlying this tumorigenic conversion. In vivo, persistent PDGF-B expression induced...

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Source

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Identifiers

PMID: 17071599
DOI: 10.2353/ajpath.2006.060120
PMCID: PMC1780216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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