Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis.

Osteoarthritis and cartilage - 1 May 2010

Valdes A M, Arden N K, Tamm A, Kisand K, Doherty S, Pola E, Cooper C, Tamm A, Muir K R, Kerna I, Hart D, O'Neil F, Zhang W, Spector T D, Maciewicz R A, Doherty M

Abstract excerpt

OBJECTIVE: Interleukin-6 is a pro-inflammatory cytokine involved in the pathogenesis of osteoarthritis (OA). We investigated the role of two single nucleotide polymorphisms (SNPs) mapping to the promoter of the IL-6 gene on genetic susceptibility to hip and knee OA. METHODS: The -174G/C (rs180079...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Interleukin-6

Share to Osteoarthritis, Hip

Share to Osteoarthritis, Knee

Share to Promoter Regions, Genetic

Share to Risk Factors

Source

Identifiers

PMID: 20175976
DOI: 10.1016/j.joca.2009.12.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20175976-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis.PMID 20175976Read ↗

Association of rs1800795 and rs1800796 polymorphisms in interleukin-6 gene and osteoarthritis risk: evidence from a meta-analysis.Semantic proximity Read ↗

Promoter polymorphisms in IL-6 gene influence pro-inflammatory cytokines for the risk of osteoarthritis.Semantic proximity Read ↗

Interleukin-6 gene polymorphism and risk of osteoarthritis of the hip: a case-control study.Semantic proximity Read ↗

Association of interleukin-6 gene polymorphism (rs1800796) with severity and functional status of osteoarthritis in elderly individuals.Semantic proximity Read ↗

Effect of IL-6 -174G/C and -572G/C variants on susceptibility to osteoarthritis in Turkish population.Semantic proximity Read ↗

The association between interleukin-6 promoter polymorphisms and rheumatoid arthritis by ethnicity: A meta-analysis of 33 studies.Semantic proximity Read ↗

Association of cytokine gene polymorphisms with osteoarthritis susceptibilitySemantic proximity Read ↗

Interleukin-1 genetic polymorphisms in knee osteoarthritis: What do we know? A meta-analysis and systematic review.Semantic proximity Read ↗

The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

The IL-6 rs12700386 polymorphism is associated with an increased risk of developing osteoarthritis in the knee in the Chinese Han population: a case-control studySemantic proximity Read ↗

Relationship between polymorphisms in -572G/C interleukin 6 promoter gene polymorphisms (rs1800796) and risk of rheumatoid arthritis: A meta-analysis.Semantic proximity Read ↗

Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.