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Article

Yos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation.

Molecular biology of the cell - 1 Apr 2012

Izawa Toshiaki, Nagai Hiroyuki, Endo Toshiya, Nishikawa Shuh-ichi

Abstract excerpt

The endoplasmic reticulum (ER) has an elaborate quality control system, which retains misfolded proteins and targets them to ER-associated protein degradation (ERAD). To analyze sorting between ER retention and ER exit to the secretory pathway, we constructed fusion proteins containing both folded carboxypeptidase Y (CPY) and misfolded mutant CPY (CPY*) units. Although the luminal Hsp70 chaperone BiP interacts...

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Identifiers

PMID: 22298424
DOI: 10.1091/mbc.E11-08-0722
PMCID: PMC3315801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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