Article
A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD.
Current genetics - 1 Apr 2022
Nakatsukasa Kunio, Wigge Sylvia, Takano Yuki, Kawarasaki Tomoyuki, Kamura Takumi, Brodsky Jeffrey L
Abstract excerpt
Misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytosol for ubiquitination and degradation by the proteasome. During this process, known as ER-associated degradation (ERAD), the ER-embedded Hrd1 ubiquitin ligase plays a central role in recognizing, ubiquitinating, and retrotranslocating scores of lumenal and integral membrane proteins. To better define the mechanisms underlying...
Topics
- Endoplasmic Reticulum
- Endoplasmic Reticulum-Associated Degradation
- Membrane Proteins
- Mutation
- Selection, Genetic
- Ubiquitin-Protein Ligases