Article
Spatial bistability generates hunchback expression sharpness in the Drosophila embryo.
PLoS computational biology - 26 Sept 2008
Lopes Francisco J P, Vieira Fernando M C, Holloway David M, Bisch Paulo M, Spirov Alexander V
Abstract excerpt
During embryonic development, the positional information provided by concentration gradients of maternal factors directs pattern formation by providing spatially dependent cues for gene expression. In the fruit fly, Drosophila melanogaster, a classic example of this is the sharp on-off activation of the hunchback (hb) gene at midembryo, in response to local concentrations of the smooth anterior-posterior Bicoid...
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