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Article

Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila.

Nature communications - 1 Jan 2013

Liu Junbo, Ma Jun

Abstract excerpt

The Drosophila morphogen gradient of Bicoid (Bcd) initiates anterior-posterior (AP) patterning; however, it is poorly understood how its ability to activate a target gene may have an impact on this process. Here we report an F-box protein, Dampened (Dmpd) as a nuclear cofactor of Bcd that can enhance its activating potency. We establish a quantitative platform to specifically investigate two parameters of a Bcd...

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Identifiers

PMID: 24336107
DOI: 10.1038/ncomms3968
PMCID: PMC3902774

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