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Article

Gene expression noise in spatial patterning: hunchback promoter structure affects noise amplitude and distribution in Drosophila segmentation.

PLoS computational biology - 3 Feb 2011

Holloway David M, Lopes Francisco J P, da Fontoura Costa Luciano, Travençolo Bruno A N, Golyandina Nina, Usevich Konstantin, Spirov Alexander V

Abstract excerpt

Positional information in developing embryos is specified by spatial gradients of transcriptional regulators. One of the classic systems for studying this is the activation of the hunchback (hb) gene in early fruit fly (Drosophila) segmentation by the maternally-derived gradient of the Bicoid (Bcd) protein. Gene regulation is subject to intrinsic noise which can produce variable expression. This variability must...

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Identifiers

PMID: 21304932
DOI: 10.1371/journal.pcbi.1001069
PMCID: PMC3033364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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