Article
Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity.
Experimental cell research - 1 Nov 2008
Ikeda Kikuko, Nakayama Yuji, Togashi Yuuki, Obata Yuuki, Kuga Takahisa, Kasahara Kousuke, Fukumoto Yasunori, Yamaguchi Naoto
Abstract excerpt
Src-family kinases, cytoplasmic enzymes that participate in various signaling events, are found at not only the plasma membrane but also subcellular compartments, such as the nucleus, the Golgi apparatus and late endosomes/lysosomes. Lyn, a member of the Src-family kinases, is known to play a role in DNA damage response and cell cycle control in the nucleus. However, it is still unclear how the localization of...
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