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Article

Stress-induced nuclear export of 5-lipoxygenase.

Biochemical and biophysical research communications - 9 Dec 2005

Hanaka Hiromi, Shimizu Takao, Izumi Takashi

Abstract excerpt

A key enzyme for leukotriene biosynthesis is 5-lipoxygenase (5-LO), which we found is exported from the nucleus when p38 MAPK is activated. CHO-K1 cells stably express green fluorescent protein-5-lipoxygenase fusion protein (GFP-5LO), which is located predominantly in the nucleus, and is exported by anisomycin, hydrogen peroxide, and sorbitol, with activation of p38 MAPK. SB203580, an inhibitor of p38 MAPK, and...

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Identifiers

PMID: 16165096
DOI: 10.1016/j.bbrc.2005.09.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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