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Article

Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit.

The Journal of biological chemistry - 11 Jun 2010

Flegg Cameron P, Sharma Manisha, Medina-Palazon Cahora, Jamieson Cara, Galea Melanie, Brocardo Mariana G, Mills Kate, Henderson Beric R

Abstract excerpt

Protein phosphatase (PP) 2A is a heterotrimeric enzyme regulated by specific subunits. The B56 (or B'/PR61/PPP2R5) class of B-subunits direct PP2A or its substrates to different cellular locations, and the B56alpha, -beta, and -epsilon isoforms are known to localize primarily in the cytoplasm. Here we studied the pathways that regulate B56alpha subcellular localization. We detected B56alpha in the cytoplasm and...

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PMID: 20378546
DOI: 10.1074/jbc.M109.093294
PMCID: PMC2881738

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