Article
Voltage-gated calcium channels provide an alternate route for iron uptake in neuronal cell cultures.
Neurochemical research - 1 Oct 2007
Gaasch Julie A, Geldenhuys Werner J, Lockman Paul R, Allen David D, Van der Schyf Cornelis J
Abstract excerpt
Recent studies suggest that iron enters cardiomyocytes via the L-type voltage-gated calcium channel (VGCC). The neuronal VGCC may also provide iron entry. As with calcium, extraneous iron is associated with the pathology and progression of neurodegenerative diseases such as Parkinson's and Alzheimer's disease. VGCCs, ubiquitously expressed, may be an important route of excessive entry for both iron and calcium,...
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