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Article

Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus.

Experimental neurology - 1 Apr 2008

Nuñez Joseph L, McCarthy Margaret M

Abstract excerpt

Clinical evidence and animal models indicate greater brain damage in newborn males following injury. In adults, glutamate is the primary source of excitotoxic cell death and the steroid, estradiol, is neuroprotective. In neonatal brain, membrane depolarization following activation of GABAA receptors is the major source of excitation. Consequent influx of calcium via L-type channels is normally trophic, but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18289534
DOI: 10.1016/j.expneurol.2008.01.001
PMCID: PMC2430990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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