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Article

Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women

14 Aug 2017

Abstract excerpt

Women have a higher risk of lethal arrhythmias than men in long QT syndrome type 2 (LQTS2), but the mechanisms remain uncertain due to the limited availability of healthy control human tissue. We have previously reported that in female rabbits, estrogen increases arrhythmia risk in drug-induced LQTS2 by upregulating L-type Ca 2+ (I Ca,L ) and sodium-calcium exchange (I NCX ) currents at the base of the epicardium...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 28807015
DOI: 10.1186/s13293-017-0148-4

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