Article
A novel AKT3 mutation in melanoma tumours and cell lines.
British journal of cancer - 21 Oct 2008
Davies M A, Stemke-Hale K, Tellez C, Calderone T L, Deng W, Prieto V G, Lazar A J F, Gershenwald J E, Mills G B
Abstract excerpt
Recently, a rare activating mutation of AKT1 (E17K) has been reported in breast, ovarian, and colorectal cancers. However, analogous activating mutations in AKT2 or AKT3 have not been identified in any cancer lineage. To determine the prevalence of AKT E17K mutations in melanoma, the most aggressive form of skin cancer, we analysed 137 human melanoma specimens and 65 human melanoma cell lines for the previously...
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