Article

AKT2 Loss Impairs BRAF-Mutant Melanoma Metastasis

2023-08-24

Abstract excerpt

Despite recent advances in treatment, melanoma remains the deadliest form of skin cancer, due to its highly metastatic nature. Melanomas harboring oncogenic BRAF V600E mutations combined with PTEN loss exhibit unrestrained PI3K/AKT signaling and increased invasiveness. However, the contribution of different AKT isoforms to melanoma initiation, progression, and metastasis has not been comprehensively explored, and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9df73395-7e0b-5f6c-9102-3709690efe7e
DOI: 10.1101/2023.08.24.554685

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AKT2 Loss Impairs BRAF-Mutant Melanoma MetastasisDOI 10.1101/2023.08.24.554685Read

RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and TherapySemantic proximity Read

Navigating the Therapeutic Complexity of PI3K Pathway Inhibition in MelanomaSemantic proximity Read

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.Semantic proximity Read

A Signal Transduction Pathway from TGF-β1 to SKP2 via Akt1 and c-Myc and its Correlation with Progression in Human MelanomaSemantic proximity Read

Focal adhesion kinase promotes metastasis in BRAF-mutant melanomaSemantic proximity Read

BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma modelSemantic proximity Read

PERK mediates resistance to BRAF inhibition in melanoma with impaired PTENSemantic proximity Read

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteinsSemantic proximity Read

AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma.Semantic proximity Read

The glycolysis regulator PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanomaSemantic proximity Read

A novel AKT3 mutation in melanoma tumours and cell lines.Semantic proximity Read

The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation.Semantic proximity Read