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Article

AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection.

BMC cancer - 11 Aug 2016

Rudolph Marion, Anzeneder Tobias, Schulz Anke, Beckmann Georg, Byrne Annette T, Jeffers Michael, Pena Carol, Politz Oliver, Köchert Karl, Vonk Richardus, Reischl Joachim

Abstract excerpt

BACKGROUND: The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise role in disease etiology remains unknown. METHODS: We analyzed more than 600 breast cancer tumor samples and circulating tumor DNA for AKT1 (E17K) and alterations in other cancer-associated genes using Beads, Emulsions, Amplification, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27515171
DOI: 10.1186/s12885-016-2626-1
PMCID: PMC4982009

Genes

AKT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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