Article
Absence of AKT1 mutations in glioblastoma.
PloS one - 20 May 2009
Bleeker Fonnet E, Lamba Simona, Zanon Carlo, van Tilborg Angela A, Leenstra Sieger, Troost Dirk, Hulsebos Theo, Vandertop W Peter, Bardelli Alberto
Abstract excerpt
BACKGROUND: Oncogenic activation of the PI3K signalling pathway plays a pivotal role in the development of glioblastoma multiforme (GBM). A central node in PI3K downstream signalling is controlled by the serine-threonine kinase AKT1. A somatic mutation affecting residue E17 of the AKT1 gene has recently been identified in breast and colon cancer. The E17K change results in constitutive AKT1 activation, induces...
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