Article
Mitochondrial superclusters influence age of onset of Parkinson's disease in a gender specific manner in the Cypriot population: A case-control study.
PloS one - 1 Jan 2017
Georgiou Andrea, Demetriou Christiana A, Heraclides Alexandros, Christou Yiolanda P, Leonidou Eleni, Loukaides Panayiotis, Yiasoumi Elena, Panagiotou Dimitris, Manoli Panayiotis, Thomson Pippa, Loizidou Maria A, Hadjisavvas Andreas, Zamba-Papanicolaou Eleni
Abstract excerpt
BACKGROUND: Despite evidence supporting an involvement of mitochondrial dysfunction in the pathogenesis of some neurodegenerative disorders, there are inconsistent findings concerning mitochondrial haplogroups and their association to neurodegenerative disorders, including idiopathic Parkinson's disease (PD). METHODS: To test this hypothesis for the Greek-Cypriot population, a cohort of 230 PD patients and 457...
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