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Mitochondrial DNA variants modulate genetic susceptibility to Parkinson's disease in Han Chinese.

Neurobiology of disease - 1 Jun 2018

Wu Hong-Mei, Li Ting, Wang Zhen-Feng, Huang Shi-Shi, Shao Zi-Qiang, Wang Ke, Zhong Hai-Qing, Chen Song-Fang, Zhang Xiong, Zhu Jian-Hong

Abstract excerpt

It is well recognized that mitochondrial dysfunction is involved in the pathogenesis of Parkinson's disease (PD). The mtDNA displacement loop (D-loop) region is known to accumulate structural alterations and mutations. To understand how mtDNA variants contribute to the susceptibility to sporadic PD in Chinese, a total of 500 PD patients and 505 controls were recruited from East China, and their D-loop regions...

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PMID: 29486294
DOI: 10.1016/j.nbd.2018.02.015

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