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Article

Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2.

Cell - 20 Apr 2007

Zhao Yong, Ransom Joshua F, Li Ankang, Vedantham Vasanth, von Drehle Morgan, Muth Alecia N, Tsuchihashi Takatoshi, McManus Michael T, Schwartz Robert J, Srivastava Deepak

Abstract excerpt

MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regulate the expression of proteins generated from messenger RNA transcripts. The in vivo requirement of specific miRNAs in mammals through targeted deletion remains unknown, and reliable prediction of mRNA targets is still problematic. Here, we show that miRNA biogenesis in the mouse heart is essential for cardiogenesis. Furthermore,...

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Source

Identifiers

PMID: 17397913
DOI: 10.1016/j.cell.2007.03.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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