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Article

Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse.

Immunological reviews - 1 Dec 2006

Tassi Ilaria, Klesney-Tait Julia, Colonna Marco

Abstract excerpt

Natural killer (NK) cell cytotoxicity is mediated by multiple germ line-encoded activating receptors that recognize specific ligands expressed by tumor cells and virally infected cells. These activating receptors are opposed by NK inhibitory receptors, which recognize major histocompatibility complex class I molecules on potential targets, raising the threshold for NK cell activation. Once an abnormal cell has...

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Identifiers

PMID: 17100878
DOI: 10.1111/j.1600-065X.2006.00463.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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