The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases

doi:10.2174/1874312901206010245

Article

The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases

7 Sept 2012

Abstract excerpt

The class 1 PI3Ks are lipid kinases with key roles in cell surface receptor-triggered signal transduction pathways. Two isoforms of the catalytic subunits, p110γ and p110δ, are enriched in leucocytes in which they promote activation, cellular growth, proliferation, differentiation and survival through the generation of the second messenger PIP3. Genetic inactivation or pharmaceutical inhibition of these PI3K...

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