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Article

Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors.

BMC neuroscience - 22 Sept 2008

Wislet-Gendebien Sabine, Visanji Naomi P, Whitehead Shawn N, Marsilio Diana, Hou Weimin, Figeys Daniel, Fraser Paul E, Bennett Steffany A L, Tandon Anurag

Abstract excerpt

BACKGROUND: Alpha-Synuclein (alpha-syn), a 140 amino acid protein associated with presynaptic membranes in brain, is a major constituent of Lewy bodies in Parkinson's disease (PD). Three missense mutations (A30P, A53T and E46K) in the alpha-syn gene are associated with rare autosomal dominant forms of familial PD. However, the regulation of alpha-syn's cellular localization in neurons and the effects of the...

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Identifiers

PMID: 18808659
DOI: 10.1186/1471-2202-9-92
PMCID: PMC2562387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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