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Article

Genomic Analysis Reveals a Common Breakpoint in Amplifications of the Plasmodium vivax Multidrug Resistance 1 Locus in Thailand.

The Journal of infectious diseases - 15 Oct 2016

Auburn Sarah, Serre David, Pearson Richard D, Amato Roberto, Sriprawat Kanlaya, To Sheren, Handayuni Irene, Suwanarusk Rossarin, Russell Bruce, Drury Eleanor, Stalker Jim, Miotto Olivo, Kwiatkowski Dominic P, Nosten Francois, Price Ric N

Abstract excerpt

In regions of coendemicity for Plasmodium falciparum and Plasmodium vivax where mefloquine is used to treat P. falciparum infection, drug pressure mediated by increased copy numbers of the multidrug resistance 1 gene (pvmdr1) may select for mefloquine-resistant P. vivax Surveillance is not undertaken routinely owing in part to methodological challenges in detection of gene amplification. Using genomic data on 88...

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Identifiers

PMID: 27456706
DOI: 10.1093/infdis/jiw323
PMCID: PMC5034950

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Source receipt: pubmed, retrieved 7 Sept 2026.

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