Article
Genetic polymorphism in pvmdr1 and pvcrt-o genes in relation to in vitro drug susceptibility of Plasmodium vivax isolates from malaria-endemic countries.
Acta tropica - 1 Feb 2011
Lu Feng, Lim Chae Seung, Nam Deok-Hwa, Kim Kwonkee, Lin Khin, Kim Tong-Soo, Lee Hyeong-Woo, Chen Jun-Hu, Wang Yue, Sattabongkot Jetsumon, Han Eun-Taek
Abstract excerpt
Treatment failure of chloroquine for Plasmodium vivax infection has increased in endemic countries. However, the molecular mechanisms for resistance and in vitro susceptibility of P. vivax to chloroquine remain elusive. We investigated the prevalence of mutations in the pvmdr1 and pvcrt-o genes, and the copy number of the pvmdr1 gene in isolates from the Republic of Korea (ROK), Thailand, the Union of Myanmar...
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