Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration.

Investigative ophthalmology & visual science - 1 Feb 2009

McKay Gareth J, Silvestri Giuliana, Patterson Christopher C, Hogg Ruth E, Chakravarthy Usha, Hughes Anne E

Abstract excerpt

PURPOSE: Polymorphic variation in genes involved in regulation of the complement system has been implicated as a major cause of genetic risk, in addition to the LOC387715/HTRA1 locus and other environmental influences. Previous studies have identified polymorphisms in the complement component 2 (CC2) and factor B (CFB) genes, as potential functional variants associated with AMD, in particular CFB R32Q and CC2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement C2
Share to Complement Factor B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Factor H

Share to DNA Helicases

Share to Linkage Disequilibrium

Share to Logistic Models

Share to Macular Degeneration

Share to Proteins

Source

Identifiers

PMID: 18806297
DOI: 10.1167/iovs.08-2275

Genes

CFB
HTRA1
CFH

Variants

rs547154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration.PMID 18806297Read ↗

Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration.Semantic proximity Read ↗

The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration.Semantic proximity Read ↗

C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes.Semantic proximity Read ↗

Analysis of rare variants in the complement component 2 (C2) and factor B (BF) genes refine association for age-related macular degeneration (AMD).Semantic proximity Read ↗

Complement factor H variant increases the risk of age-related macular degeneration.Semantic proximity Read ↗

Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.Semantic proximity Read ↗

Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.Semantic proximity Read ↗

Genetic Association of Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy.Semantic proximity Read ↗

Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration.Semantic proximity Read ↗

Unraveling a complex genetic disease: age-related macular degeneration.Semantic proximity Read ↗

A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.Semantic proximity Read ↗

Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.