Article
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
Genes and immunity - 1 Dec 2010
Kopplin L J, Igo R P, Wang Y, Sivakumaran T A, Hagstrom S A, Peachey N S, Francis P J, Klein M L, SanGiovanni J P, Chew E Y, Pauer G J T, Sturgill G M, Joshi T, Tian L, Xi Q, Henning A K, Lee K E, Klein R, Klein B E K, Iyengar S K
Abstract excerpt
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in the developed world. We conducted a genome-wide association study in a series of families enriched for AMD and completed a meta-analysis of this new data with results from reanalysis of an existing study of a late-stage case-control cohort. We tested the top findings for replication in 1896 cases and 1866 controls and...
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