Article
Complement factor H variant increases the risk of age-related macular degeneration.
Science (New York, N.Y.) - 15 Apr 2005
Haines Jonathan L, Hauser Michael A, Schmidt Silke, Scott William K, Olson Lana M, Gallins Paul, Spencer Kylee L, Kwan Shu Ying, Noureddine Maher, Gilbert John R, Schnetz-Boutaud Nathalie, Agarwal Anita, Postel Eric A, Pericak-Vance Margaret A
Abstract excerpt
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD. We used single-nucleotide polymorphisms to interrogate this region and identified a strongly associated haplotype in two independent data sets. DNA resequencing of the complement...
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